Abstract
There is clinical and experimental evidence that the response to hypoxic and hypoxic-ischemic brain injury is age dependent. The effects of perinatal hypoxia, especially its epileptogenic effects, are different in the neonatal brain compared with that of the adult. Experimental models show increased susceptibility of the immature brain to the epileptogenic and toxic effects of hypoxia and hypoxia-ischemia. This article reviews several maturational factors that are likely to contribute to the enhanced vulnerability of the immature brain. Some of the factors known to be involved in the pathophysiology of hypoxic-ischemic encephalopathy are also known to be critical for normal brain development. These issues are discussed in the context of defining age-specific therapies to prevent hypoxic-ischemic neuronal injury in the immature brain. MRDD Research Reviews 3:85–95, 1997. © 1997 Wiley-Liss, Inc.
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