Abstract

Background: Attention deficit hyperactivity disorder is a common pediatric neurobehavioral disorder often treated in the primary care setting. It shows a high and chronic level of inattention, impulsivity/hyperactivity and/or both, and can affect more than 2 million school-age children. The researchers are not sure about the exact causes of the disorder, but it seems that apart from genetic factors, perinatal factors seem to dynamically contribute to the development of the disorder. Purpose: The aim of this review was to investigate the perinatal and obstetric factors related to the development of the attention deficit hyperactivity disorder in childhood. Method: An online review of English language studies published from 2002 to 2020, using the Embase, PsychINFO, PubMed and Google Scholar databases. From 1100 studies only 17 were included in the review since they met the inclusion criteria. Conclusions: The results of the review showed that apart from heredity and genetic factors, various conditions in pregnancy or the mother’s way of life in pregnancy, adverse conditions in labor and infancy can contribute on their own or in combination to the development of the attention deficit hyperactivity disorder in childhood. Obstetric vigilance to detect risk factors in pregnancy in combination with the prevention of obstetric complications is the key in preventing attention deficit hyperactivity disorder.

Highlights

  • Attention deficit hyperactivity disorder is a common pediatric neurobehavioral disorder often treated in the primary care setting

  • The aim of this review was to investigate the perinatal and obstetric factors related to the development of the attention deficit hyperactivity disorder in childhood

  • Obstetric vigilance to detect risk factors in pregnancy in combination with the prevention of obstetric complications is the key in preventing attention deficit hyperactivity disorder

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Summary

Causes of ADHD

ADHD, as other common medical and mental disorders, is affected by multiple genes, non-hereditary factors and their interaction [16]. Hereditary contribution plays a big role in ADHD. Various studies have found steadily higher ADHD percentages (up to eight times) in parents and siblings of affected people compared to relatives of non-affected controls [17]. Various researchers have found that there is dopamine deficit in ADHD children and that its antagonist, methylphenidate, can therapeutically help. The interaction of dopamine and glutamic acid, released in the corpus striatum, has been blamed for the cognitive function of these people, while the serotonin/SNAP-25 protein disorder seems to result in the hyperactivity symptom in ADHD patients [19]

Gender Differences in ADHD
Perinatal Factors of ADHD
Design
Findings
Antoniou et al DOI
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