Perinatal factors affecting platelet parameters in late preterm and term neonates.

Hayato Go,Nobuo Momoi,Yukihiko Kawasaki,Mina Chishiki,Masato Hoshino,Mitsuaki Hosoya,Hitoshi Ohto,Kei Ogasawara,Nozomi Kashiwabara,Kenneth E Nollet,Kelli K Ryckman

doi:10.1371/journal.pone.0242539

Abstract

Platelets parameters including platelet count (PLT), plateletcrit (PCT), mean platelet volume (MPV) and platelet distribution width (PDW) are associated with various physiological and pathological functions in various disease. However, few studies have addressed whether perinatal factors may be associated with platelet parameters at birth in a large cohort of late preterm and term neonates. The aim of this study to investigate perinatal factors affecting platelet parameters in late preterm and term neonates. We retrospectively investigated platelet parameters including PLT, PCT, MPV, and PDW on the first day of life in 142 late preterm and 258 term neonates admitted to our NICU from 2006 through 2020. PLT, MPV, PCT, PDW on Day 0 did not significantly differ between the two groups. In term neonates, multivariate analysis revealed that PCT correlated with being small for gestational age (SGA) (β = -0.168, P = 0.006), pregnancy induced hypertension (PIH) (β = -0.135, P = 0.026) and male sex (β = -0.185, P = 0.002). PLT was associated with SGA (β = -0.186, P = 0.002), PIH (β = -0.137, P = 0.024) and male sex (β = -0.166, P = 0.006). In late preterm neonates, multivariate analysis revealed that PLT were associated with PIH, whereas no factors associated with PDW and MPV were found. In all patients studied, chorioamnionitis (CAM) was significantly associated with MPV (CAM = 10.3 fL vs. no CAM = 9.7 fL, P<0.001). Multivariate analysis showed that SGA, male sex and PIH were associated with PCT and PLT. This study demonstrates that different maternal and neonatal complications affect platelet parameters in late preterm and term neonates.

Highlights

Platelets parameters including platelet count (PLT), plateletcrit (PCT), mean platelet volume (MPV) and platelet distribution width (PDW) are associated with various physiological and pathological functions in various disease [1,2,3]
We considered pregnancy-induced hypertension (PIH), chorioamnionitis (CAM, defined clinically, with histopathological confirmation in pre-term placentas) [16]. premature rupture of membranes (PROM), and placental abruption (PA) as possible prenatal risk factors, and small for gestational age (SGA), respiratory distress syndrome (RDS), and Apgar scores as possibly associated with platelet parameters
There are no significant differences in platelet parameters between late preterm and term neonates

Summary

Introduction

Platelets parameters including platelet count (PLT), plateletcrit (PCT), mean platelet volume (MPV) and platelet distribution width (PDW) are associated with various physiological and pathological functions in various disease [1,2,3]. Platelet production is a complex process arising from the proliferation and differentiation of megakaryocytes under the stimulating. Platelet parameters in late and term neonates financial support. Funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript

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Methods

Conclusion