Perinatal environmental influences on goat's and sheep's milk allergy without cow's milk allergy

Abstract

Cow's milk (CM) allergy is the most common food allergy in children, and it can coincide with goat's and sheep's milk (GSM) allergy because of high sequence homology between the corresponding proteins. [1] Jarvinen K.M. Chatchatee P. Mammalian milk allergy: clinical suspicion, cross reactivities and diagnosis. Curr Opin Allergy Clin Immunol. 2009; 9: 251-258 Crossref PubMed Scopus (79) Google Scholar Conversely, GSM allergy without CM allergy is extremely rare and mainly reported in countries with higher consumption of GSM products. [2] Rodriguez del Rio P. Sanchez-Garcia S. Escudero C. et al. Allergy to goat's and sheep's milk in a population of cow's milk allergy children treated with oral immunotherapy. Pediatr Allergy Immunol. 2012; 23: 128-132 Crossref PubMed Scopus (32) Google Scholar The reasons for the development of GSM allergy without CM allergy are unclear, but identical twin studies could shed light on this issue. We describe a case of monoamniotic identical twin girls with disparate food allergy. Twin A developed GSM allergy without CM allergy, and twin B has not yet manifested any food allergy.