Abstract
The high dietary triglyceride intake in the perinatal period of all mammals including man occurs when the lipolytic activity in the gastrointestinal tract is low. In previous experiments the activity of one of the enzymes of the re-esterification pathway, acyl-CoA:monoglyceride acyltransferase was found to be higher in microsomes prepared from suckling rat jejunal mucosa than in adults(Experientia 29, 405, 1973). To evaluate conclusively the esterification processes during the suckling period, the activity of the fatty acid: CoA ligase in jejunal microsomes and the in-vitro esterification of 1-14C-oleic acid by jejunal segments was determined. The activity of the fatty acid:CoA ligase in newborn, 5, 12 and 90 day old rats was 239±15, 154±24, 149±10 and 195±21 nmoles/min/mg protein, respectively. The results of these enzymological studies were confirmed by the finding that the esterification rate of oleic acid occurs as rapidly in jejunal mucosa of suckling rats as in adults. Thus these studies indicate that, of the phases of fat absorption, the re-esterification processes are not a limiting factor. The apparent discrepancy of low lipolytic and high esterification activity during the suckling period remains to be explained.
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