Abstract
Perinatal Case Fatality Rate Related to Congenital Zika Syndrome in Brazil: A Cross-Sectional Study
Highlights
Many studies have demonstrated a causal link between Zika virus (ZIKV) infection, microcephaly (MCP), and other congenital abnormalities (CA)
The six cases related to ZIKV were confirmed by RT–PCR and/or IgM/IgG antibodies against ZIKV
This study highlights a high rate of perinatal lethality (15.78%) in cases of Congenital Zika Syndrome (CZS)
Summary
Many studies have demonstrated a causal link between Zika virus (ZIKV) infection, microcephaly (MCP), and other congenital abnormalities (CA). This study aimed to determine perinatal case fatality rate in cases of Congenital Zika Syndrome (CZS) in the Rio Grande do Norte State (RN), a Brazilian Northeast State highly impacted by the Zika virus outbreak. Up to 15% of pregnancies complicated by maternal ZIKV infection result in Zika-virus associated brain abnormalities in the fetus/newborn. Perinatal HSV is associated with ~60% mortality if untreated and with substantial morbidity even with appropriate therapy. Immunization with ΔgD-2 completely protects adult mice from HSV-1 and HSV-2 disease following vaginal, skin, intraocular, or intranasal challenge and prevents the establishment of latency (ELife, 2014, JCI Insight, 2016). We hypothesize that maternal immunization with ΔgD-2 and/or passive transfer of immune serum will protect neonates from HSV. We correlated blood VL before and during therapy with clinical findings at presentation and follow-up in this population
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