Perinatal astemizole exposure in the rat throughout gestation: Long-term behavioral and anatomic effects associated with reproduction

Abstract

Astemizole (ATZ), a non-sedative antihistamine, which antagonize histamine at the level of H1 receptor, was administered daily to female Wistar rats as a 10-mg/kg dose throughout pregnancy. ATZ exposure reduced offspring body weight and delayed the pinna detachment and startle reflex without any modification of dams body weight during gestation. Long-term disruption of male reproductive behavior was seen in experimental animals, whereas female sexual behavior was not modified. In addition, no motor alterations were observed in female or males in adulthood. Testis wet weight was reduced, but no modifications were detected in vasa deferentia or seminal vesicle. We proposed that ATZ administration during pregnancy causes several effects mainly of a sexual nature by interfering either with the hormonal mechanism involved in the central nervous system masculinization or by a direct action of the drug on pups during the development.