Abstract
Pericytes are perivascular cells that envelop and make intimate connections with adjacent capillary endothelial cells. Recent studies show that they may have a profound impact in skeletal muscle regeneration, innervation, vessel formation, fibrosis, fat accumulation, and ectopic bone formation throughout life. In this review, we summarize and evaluate recent advances in our understanding of pericytes' influence on adult skeletal muscle pathophysiology. We also discuss how further elucidating their biology may offer new approaches to the treatment of conditions characterized by muscle wasting.
Highlights
AGING NEUROSCIENCEPericytes: multitasking cells in the regeneration of injured, diseased, and aged skeletal muscle
In skeletal muscle, small blood vessels called capillaries surround each myofiber (Poole et al, 2008)
The word pericyte derives from the Greek kytos, a hollow vessel, appropriately describing a cell surrounding a blood vessel
Summary
Pericytes: multitasking cells in the regeneration of injured, diseased, and aged skeletal muscle. Alexander Birbrair 1,2, Tan Zhang 1, Zhong-Min Wang 1, Maria L. Messi 1, Akiva Mintz 3 and Osvaldo Delbono 1,2*. Reviewed by: Aurel Popa-Wagner, University of Medicine Rostock, Germany Marni Della Boppart, University of Illinois at Urbana-Champaign, USA Cesare Gargioli, University of Rome Tor Vergata, Italy. Pericytes are perivascular cells that envelop and make intimate connections with adjacent capillary endothelial cells. Recent studies show that they may have a profound impact in skeletal muscle regeneration, innervation, vessel formation, fibrosis, fat accumulation, and ectopic bone formation throughout life. We summarize and evaluate recent advances in our understanding of pericytes’ influence on adult skeletal muscle pathophysiology. We discuss how further elucidating their biology may offer new approaches to the treatment of conditions characterized by muscle wasting
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