Abstract
Perichondritis auricularis: initial presentation of ANCA-associated vasculitis A 74-year-old woman consulted with persisting fever, tenderness of the ear and renal failure. The initial examination showed a systemic inflammatory process of unknown origin and clinical signs of perichondritis. Inflammatory and renal function deterioration under antibiotic treatment justified auto-immune serology and a kidney biopsy, which resulted in the diagnosis of PR3-ANCA (antineutrophil cytoplasmic antibodies) positive granulomatosis with polyangiitis (GPA). The patient was treated with corticoids and rituximab, under which she made a slow but steady recovery. In patients presenting with perichondritis and systemic inflammation, it remains important to include auto-immune diseases (such as GPA) into the differential diagnosis.
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