Abstract
Ischemic heart disease (IHD) remains a leading cause of mortality. After myocardial infarction (MI), immune cell functions and phenotypes mediate maladaptive tissue remodeling with progression to heart failure. Extracellular matrix (ECM) biomaterials can modulate immune cell phenotypes and may optimize repair. Pericardial fluid contains pro-reparative immune cells that ECM biomaterials may stimulate to promote adaptive remodeling and preserve post-infarct cardiac function. Herein, we explore the impact of pericardial delivery of a micronized ECM biomaterial (porcine small intestinal submucosal extracellular matrix; mSIS-ECM) on post-infarct cardiac inflammation and tissue healing.
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