Abstract
Objective: The aim of this study was make a descriptively evaluate the repair of the periapical region of dog teeth. Material and Methods: Thirty-six root canals were used,eighteen were filled with 0.075% capsaicin and calcium hydroxide (test paste)and the rest eighteen root canals were filled with calcium hydroxide (control group). Histological analyzes were performed to classify inflammation as absent, mild, moderate or severe. The analyses also classified the presence or absence of repairat 7, 14 and 30 days.Results: The use of 0.075% capsaicin did not modify the inflammatory response and repairwhen compared to control group. Conclusion: Our data suggests that test group with 0.075% capsaicin as intracanal administration could be indicated for tissue repair; furthermore other experiments should be carried out to evaluate possible clinical use of capsaicin for atypical odontalgia.Keywords: Capsaicin; Repair; Inflammation; Periapical tissue.
Highlights
Capsaicin is a compound derived from the chili pepper extract [1]
The atypical odontalgia is a neuropathic pain characterized by discomfort in a tooth or in a site where extraction has been performed, with no clinical or radiographic signs related to disease [3]
The exudate is gradually resorbed and the neutrophilic infiltrate is replaced by mononuclear leukocytes with macrophages predominance, and these histological events could be observed in this experiment at 7 and 14 days
Summary
Capsaicin is a compound derived from the chili pepper extract [1]. Repeated applications cause a prolonged period of hypoalgesia, which is generally referred to as desensitization. Capsaicin has been recommended as treatment for a variety of neuropathic pain syndromes [2]. The atypical odontalgia is a neuropathic pain characterized by discomfort in a tooth or in a site where extraction has been performed, with no clinical or radiographic signs related to disease [3]. There is no agreement on the most appropriate therapeutic protocol for treating neuropathic pain, once this condition is difficult to diagnose and well elaborated clinical control studies to assess the effectiveness of drugs for atypical odontalgias are lacking [4]. Several drugs have been used in the treatment of atypical odontalgias and tricyclic antidepressants stand out among them [5]. Capsaicin topically applied in mucosa promotes intense irritation, characterized by the burning sensation, which leads to treatment interruption. The intracanal route could be an alternative use of capsaicin without causing adverse effects
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