Abstract

This article presents a case history of white sponge nevus (WSN) in the perianal area of a 23-year-old Hispanic female. WSN is a rare, autosomal dominant disorder that affects the noncornified stratified squamous epithelia. Clinically, the lesions are characterized by the presence of white, spongy plaques in the oral cavity. Extraoral lesions are found in other mucosal sites but are relatively uncommon in the absence of oral manifestations. Because WSN is rare, the differential diagnosis of this lesion may be difficult and the diagnosis is best made by a tissue biopsy performed in the context of a detailed patient and family history. The problems associated with differential diagnosis are addressed.

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