Abstract
We are reporting two cases of perianal squamous cell carcinoma in-situ, negative for high-risk (HR) and low-risk (LR) human papilloma viruses. A brief review of anal and perianal squamous cell carcinoma and the role of HPV are presented.
Highlights
Squamous cell carcinoma, the second most common form of skin cancer, most often affects sun-exposed surfaces
Invasive perianal squamous cell carcinoma is a locally infiltrative malignant skin tumor that exhibits destructive growth. It is a relatively uncommon tumor, which develops from the precursor lesion anal intraepithelial neoplasia (AIN)
Squamous cell carcinoma tends to develop on previously damaged skin, such as that injured by sun exposure
Summary
The second most common form of skin cancer, most often affects sun-exposed surfaces. Squamous cell carcinoma can involve skin surfaces not previously exposed to sunlight, such as in the anal and perianal regions. Invasive perianal squamous cell carcinoma is a locally infiltrative malignant skin tumor that exhibits destructive growth. It is a relatively uncommon tumor, which develops from the precursor lesion anal intraepithelial neoplasia (AIN). Case 2 A 60-year-old female was seen in the dermatology clinic for evaluation of a nonhealing, tender lesion in the intergluteal cleft. Up to one-third of anal squamous cell carcinomas appear to be associated with HPV infection. Bjørge [1], in a large case-cohort study, found that patients seropositive for HPV's 16 and 18 had an increased risk of developing anal and perianal skin cancer.
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