Abstract
The clinical appliance of perfusion is being continuously developed and it is closely related to technology development. The role of perfusion neuroimaging in the management of acute stroke has been to prove reduced regional blood flow and to give the contribution in the identification of ischemic areas, respectively the regions of hypoperfusion that can be treated by thrombolytic and/or endovascular recanalization therapy. There are two main approaches to the measurement of cerebral perfusion by magnetic resonance. The aim of this article is to compare different measuring approaches of MR perfusion neuroimaging.
Highlights
Perfusion of the tissue is the basic physiological parameter that is closely related to the function of the tissue
The role of perfusion neuroimaging in the management of acute stroke has been to prove reduced regional blood flow and to give the contribution in the identification of ischemic areas, respectively, the regions of hypoperfusion that can be treated by thrombolytic and/or endovascular recanalization therapy [2]
Dynamic susceptibility contrast enhanced (DSC) magnetic resonance (MR) perfusion, known as bolus tracking or perfusion-weighted imaging so far, has been the main MR perfusion imaging method used in diagnostics of acute stroke [4]
Summary
Perfusion of the tissue is the basic physiological parameter that is closely related to the function of the tissue. Dynamic susceptibility contrast enhanced (DSC) MR perfusion, known as bolus tracking or perfusion-weighted imaging so far, has been the main MR perfusion imaging method used in diagnostics of acute stroke [4] It is based on induced loss of signal sensitivity to T2* weighted sequences, which is the result of gadolinium-based contrast agent passing through capillary circulation. ASL is the perfusion method for quantitative measuring of cerebral blood flow (CBF) that uses arterial fluid as endogenous tracer, and it does not require the application of gadolinium contrast agents. Because of it being non-invasive, it is safe to repeat measuring, and it can be used for following the course of the disease or the effects of therapy [8]. The autoregulation maintains CBF on 50–60 mL/100 g/min [15]
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