Perfusion CT cerebral blood volume and permeability surface in low and high grades of brain glioma

Abstract

PurposeTo study if glioma grade could be correlated with perfusion CT parameters; permeability surface (PS) and cerebral blood volume (CBV) and if high-grade glioma would show different parameter levels as compared with low-grade glioma. Patients and methodsPerfusion CT (PCT) was conducted for 40 patients with untreated glioma using 64 multidetector-row CT scanner. Perfusion maps of PS and CBV were generated, and these parameters were measured. World Health Organization (WHO) glioma grades were compared with PCT parameters. ResultsThe 40 patients were classified as low-grade glioma group (18 patients) and high-grade glioma group (22patients). There was highly significant difference (P<0.001) between the two groups as regard the mean values of CBV& PS in tumor sides where they were higher in the high-grade glioma group. Receiver operating characteristic (ROC) analyses showed that PS (AUC 0.818) is better than CBV (AUC 0.788) in differentiating low- and high-grade glioma and so PS had higher predictability than CBV regarding glioma grading. ConclusionChanges in PS and CBV values had good correlation with glioma grading; with PS was the best parameter correlating with glioma grade. High grade glioma showed higher PS and CBV levels as compared with low-grade glioma.