Abstract
Lipoxygenase as well as cyclooxygenase pathways of arachidonic acid (AA) metabolism are involved in antigen-induced bronchoconstriction in ovalbumin-sensitized guinea-pig lungs. Chemical lung challenge induced by aerosol containing formaldehyde (5 ppm up to 20 ppm) was effective in increasing thromboxane (TX) B2 release in a dose-dependent manner, without affecting leukotriene (LT) release. This suggests that xenobiotics acting by non-immunologic mechanisms on bronchial mucosa may stimulate the cyclooxygenase pathway of AA metabolism, which, in turn, might cause bronchial and/or lung parenchymal effects of pathophysiological relevance.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callMore From: Archives of toxicology. Supplement. = Archiv fur Toxikologie. Supplement
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
