Abstract

In older people, adequate pharmacological tactics when using modern antihypertensive drugs and their combinations, which provide maximum cardiovascular protection, can increase the duration and improve the quality of life, significantly reduce the likelihood of complications. An increase in the tone of the sympathetic nervous system leads to biliary dyskinesia by hypokinetic type, an increase in blood pressure.
 The aim is to optimize the treatment of patients with high blood pressure, rhythm disturbances, to analyze the possibility of using Poltava's Bischofite mineral compound, dietary magnesium-mineral supplements Bisheffect, in the complex treatment of hypertension for internal use.
 Matherials and methods. 68 patients with arterial hypertension with concomitant hepatobiliary pathology, which was confirmed by clinical and instrumental research methods, were under observation. The patients’ mean age was 47.9 ± 2.9 years. The analysis of heart rate variability was carried out during a test with physical activity on a bicycle ergometer with “Cardiolab+” equipment (“XAI-Medica, Kharkiv, Ukraine). In addition, daily monitoring of blood pressure was carried out using the ABPM-04 - Meditech apparatus.
 Result. By the end of the first week of treatment, most patients (82.34%) noted a significant improvement in well-being. During bicycle ergometry, autonomic nervous system stabilisation, blood pressure normalisation, a decrease in the number of extrasystoles, the sleep and the stool normalisation were recorded. The reason for the failure of standard antiarrhythmic therapy in this group of patients was determined based on the studies. Such a problem was observed due to dysfunction of the autonomic nervous system, which is an integral companion of the pathology of the gastrointestinal tract. This concept involves expanding the diagnostic search and stimulates the search for new ways of rhythm disturbances treatment in the pathology of the gastrointestinal tract. Also, the indices of blood pressure variability have decreased. Average 24h blood pressure in patients on the 10th day of treatment decreased by an average of 25-35 mm Hg, and there was a decrease in cranialgia attacks and autonomic disorders. An increase in the blood ejection fraction by 34%, a heart's stroke volume by 19%, and a normalisation of the minute volume (p˂0.05) were revealed, which confirms the positive effect of bischofite-therapy in the complex treatment of cardiac pathology.
 Conclusions. Treatment with standard LEIT-therapy, use of dietary magnesium-mineral Bisheffect supplements resulted in the autonomic nervous system stabilisation, blood pressure normalisation, a decrease in the number of extrasystoles, the sleep and the stool normalisation, increased exercise tolerance.

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