Abstract
The SD Bioline malaria Ag- Pf/Pan performances were evaluated for malaria species detection in 215 febrile patients living in Gabon, using microscopy as gold standard. Malaria parasites were identified in 94 (43.7%) individuals by microscopy, and 104 (48.4%) patients tested positive by the RDT. The SD Bioline Ag-Pf/Pan global sensitivity was 96.8%. All the non-falciparum malaria species infections were correctly diagnosed by the rapid test. The specificity was of 89.3% and the false positive (FP) rate of 12.5%. The test sensitivity significantly increased with parasitaemia, being of 88.9% for parasite density below 100/ µL and 98.5% at density higher than 500 parasites/ µL (p<0.01). Among the patients with a negative blood smear, the proportion of FP results was 21.0% in those previously-treated with an antimalarial drug before the consultation, and 8.8% in individuals without self-medication. SD Bioline Ag-Pf/ Pan RDT represents a good alternative to microscopy for the diagnosis of Plasmodium spp infection.
Highlights
The Test-Treat-Track (T3) initiative, launched in 2012 by the World Health Organization (WHO), is a clear indication that malaria management should be based on evidences
Histidine rich protein 2 (HRP2)/pLDH comboRDTs have not been evaluated in Gabon
The present data showed overall good performances for the SD Bioline malaria Ag/Pf/Pan in the identification of P. falciparum and non-falciparum malaria infection in febrile patients living in Gabon
Summary
The Test-Treat-Track (T3) initiative, launched in 2012 by the WHO, is a clear indication that malaria management should be based on evidences. Single RDTs detecting the Histidine rich protein 2 (HRP2) or the lactate deshydrogenase (pLDH), and a HRP2/aldolase combo RDT performances were analyzed in field conditions [4,5] The SD Bioline Malaria Ag P.f/Pan test is a rapid, qualitative and differential test for the detection of HRP-II antigen of Plasmodium(P.) falciparum and common Plasmodium lactate dehydrogenase (pLDH) of Plasmodium species in human whole blood. It was one of the best performing assays in the WHO/TDR (Special Program for Research and Training in Tropical Diseases)/ FIND (Foundation for Innovative New Diagnostics)/CDC (Centers for Disease Control) evaluation.
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