Performance of the IOTA ADNEX Model on Selected Group of Patients with Borderline Ovarian Tumours.

Adrius Gaurilcikas,Daiva Vaitkiene,Vaida Atstupenaite,Migle Gedgaudaite,Ruta Jolanta Nadisauskiene,Dovile Gaurilcikiene,Arvydas Cizauskas,Tomas Birzietis,Saulius Paskauskas

doi:10.3390/medicina56120690

Adrius Gaurilcikas, Daiva Vaitkiene + Show 7 more

Open Access

https://doi.org/10.3390/medicina56120690

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Abstract

Background and objectives: ultrasound is considered to be the primary tool for preoperative assessment of ovarian masses; however, the discrimination of borderline ovarian tumours (BOTs) is challenging, and depends highly on the experience of the sonographer. The Assessment of Different NEoplasias in the adneXa (ADNEX) model is considered to be a valuable diagnostic tool for preoperative assessment of ovarian masses; however, its performance for BOTs has not been widely studied, due to the low prevalence of these tumours. The aim of this study was to evaluate the performance of ADNEX model for preoperative diagnosis of BOTs. Methods: retrospective analysis of preoperative ultrasound datasets of patients diagnosed with BOTs on the final histology after performed surgery was done at a tertiary oncogynaecology centre during the period of 2012–2018. Results: 85 patients were included in the study. The performance of ADNEX model based on absolute risk (AR) improved with the selection of a more inclusive cut-off value, varying from 47 (60.3%) correctly classified cases of BOTs, with the selected cut-off of 20%, up to 67 (85.9%) correctly classified cases of BOTs with the cut-off value of 3%. When relative risk (RR) was used to classify the tumours, 59 (75.6%) cases were identified correctly. Forty (70.2%) cases of serous and 16 (72.7%) cases of mucinous BOTs were identified when AR with a 10% cut-off value was applied, compared to 44 (77.2%) and 15 (68.2%) cases of serous and mucinous BOTs, correctly classified by RR. The addition of Ca125 improved the performance of ADNEX model for all BOTs in general, and for different subtypes of BOTs. However, the differences were insignificant. Conclusions: The International Ovarian Tumour Analysis (IOTA) ADNEX model performs well in discriminating BOTs from other ovarian tumours irrespective of the subtype. The calculation based on RR or AR with the cut-off value of at least 10% should be used when evaluating for BOTs.

Highlights

Compared to invasive ovarian cancer, borderline ovarian tumours (BOTs) are associated with a significantly better overall survival rate (59.7–99.6%, depending on the stage of the disease) [1,2], but tend to compromise younger patients [1,2,3,4]
The performance of ADNEX model based on absolute risk (AR) depends on the selected cut-off value for the malignancy risk
It is the only study on the performance of the ADNEX model with a representable set of BOT cases carried in an external center

Summary

Introduction

Compared to invasive ovarian cancer, borderline ovarian tumours (BOTs) are associated with a significantly better overall survival rate (59.7–99.6%, depending on the stage of the disease) [1,2], but tend to compromise younger patients [1,2,3,4]. Ultrasound is considered to be the primary tool for preoperative assessment of ovarian masses [7,8]; Medicina 2020, 56, x FOR PEER REVIEW the discrimination of BOTs is challenging, and the accuracy of the diagnosis depends highly on the experience of the sonographer [7,9]. In 2014, the International Ovarian Tumour Analysis (IOTA) group delivered the Assessment of considered to be the primary tool for preoperative assessment of ovarian masses [7,8]; the Different NEoplasias in the adneXa (ADNEX) model, which is the first risk model to differentiate benign discrimination of BOTs is challenging, and the accuracy of the diagnosis depends highly on the ovarian tumours, BOTs, stage I invasive cancer, stage II–IV invasive ovarian cancer, and secondary experience of the sonographer [7,9].

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