Performance of PAC1-R Heterozygous Mice in Memory Tasks-II

Abstract

An involvement of pituitary adenylate cyclase activating polypeptide-specific receptor type 1 (PAC1-R) in behavioral performance of retrieval of memory upon the stimulation of perception of sensory modality was investigated in mice. Eighteen heterozygous (-/+) transgenic mutant PAC1-R-deficient mice ((-/+) mice) and 18 wild-type (+/+) mice of littermates ((+/+) mice) as a control were used. No homozygous (-/-) transgenic mutant PAC1-R-deficit mouse was bred in our colony. It was observed that; (1) changing a single alley in the multiple mazes interfered with retrieval of memory in both (-/+) mice and (+/+) mice, and they made considerable errors; (2) a rotation of the multiple mazes for 180 degrees in relation to the geomagnetic field made also considerable errors, but in only (+/+) mice and not in (-/+) mice; and (3) an exposure for perception of fear signals made also considerable errors, but in only (+/+) mice and not in (-/+) mice. It is inferred that PAC1-R may play a gating role in passage permitting through perception of geomagnetic orientation and fear signals, but not perception of visual orientation, and it regulates behavioral performance in retrieval of memory in mice.