Performance of Mattis dementia rating scale-Chinese version in patients with mild cognitive impairment and Alzheimer\u2019s disease

Shuxia Qian,Qiaobing Guan,Qihao Guo,Keliang Chen

doi:10.1186/s12883-021-02173-0

Abstract

BackgroundTo identify the applicability of the Chinese Version of Mattis Dementia Rating Scale (DRS-CV).MethodsThe DRS-CV was administered to 483 participants, including 136 normal controls, 167 patients with mild cognition impairment (MCI), and 180 patients with Alzheimer’s disease (AD). Receiver Operating Characteristic (ROC) curve was used to evaluate the sensitivity and specificity of the scale.ResultsThe scores of DRS-CV were ranked in the order of NC > MCI > mild AD > moderate AD group. Memory was the sensitive function affected at a relatively earlier stage of AD. ROC curve analysis indicated the DRS-CV total score and memory subscale showed excellent sensitivity and specificity in the discrimination between MCI from mild AD and mild AD from moderate AD, but poor sensitivity and specificity in the discrimination between MCI and NC.ConclusionThe DRS-CV is useful to the early diagnosis and severity of AD, not to the early identification of MCI.

Highlights

To identify the applicability of the Chinese Version of Mattis Dementia Rating Scale (DRS-CV)
The total scores of Minimental state examination-Chinese version (CMMSE) and Chinese Version of the Dementia Rating Scale (DRS-CV) were significantly lower in patient groups
The scores of different cognitive domains were ranked in the order of normal controls (NC) > mild cognition impairment (MCI) > mild Alzheimer’s disease (AD) > moderate AD group

Summary

Introduction

To identify the applicability of the Chinese Version of Mattis Dementia Rating Scale (DRS-CV). ROC curve analysis indicated the DRS-CV total score and memory subscale showed excellent sensitivity and specificity in the discrimination between MCI from mild AD and mild AD from moderate AD, but poor sensitivity and specificity in the discrimination between MCI and NC. The Mattis Dementia Rating Scale (DRS) was used as a screening tool to assess the cognitive function for patients with dementia. It consists of 37 tasks divided into five subscales of attention, initiation/perseveration, construction, conceptualization, and memory, with subscale scores of 37, 37, 6, 39, 25, respectively and a maximum total score of 144. The DRS provides more detailed information about a patient’s impaired and intact cognitive function than. For the first time, validates Mandarin Chinese version of DRS and further assesses the applicability of DRS

Methods

Results

Discussion

Conclusion