Abstract
Male mice (Mus musculus) 12–16 weeks of age from the C57BL/6J and DBA/2J inbred strains and B6D2F1 hybrids were trained at one of two shock levels (.5 or 2.0 mA) in a wheel-turn avoidance task during one 60-min session. Following two 10-min blocks during which no shock was given, a free-operant avoidance program was activated that required the animal to turn a wheel .5 revolution at least once every 10 sec in order to avoid a 1-sec footshock. The program was terminated when the mouse reached an acquisition criterion, which was 5 min of successful shock avoidance, or when it completed the 60-min session without reaching criterion. Strain differences in learning were marked and consistent at both shock levels. Most C57BL/6J mice reached criterion, and most DBA/2J mice failed. The performance of B6D2F1 mice matched that of the C57BL/6J strain.
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