Abstract
Abstract not available.
Highlights
Difficult-to-diagnose lesions are commonly sent for second opinions to expert dermatopathologists who have more experience with challenging cases; the nature of many lesions remains ambiguous with discordant rates of diagnoses ranging from 25-43%
The 35-gene expression profile (GEP) test has reported accuracy metrics of 99.1% sensitivity, 96.2% specificity, 96.1% positive predictive value (PPV) and 99.1% negative predictive value (NPV) within the clinically available ≥18-year-old population (n=474)
Our objective is to demonstrate accuracy of the 35-GEP within lesions located on the head and neck
Summary
The accurate diagnosis of melanocytic neoplasms is a significant clinical challenge in dermatopathology; while histopathologic assessment is frequently sufficient, high rates of diagnostic discordance are reported.. Visual assessment of hematoxylin and eosin (H&E) stained lesions is inherently subjective and relies on expert interpretation and integration of a wide spectrum of architectural and cytologic features that are weighted differently based on the presumed subtype of melanocytic neoplasm and heavily influenced by the pathologists’ personal experience and training.. Difficult-to-diagnose lesions are commonly sent for second opinions to expert dermatopathologists who have more experience with challenging cases; the nature of many lesions remains ambiguous with discordant rates of diagnoses ranging from 25-43%.1,6. The 35-gene expression profile (GEP) test has reported accuracy metrics of 99.1% sensitivity, 96.2% specificity, 96.1% positive predictive value (PPV) and 99.1% negative predictive value (NPV) within the clinically available ≥18-year-old (yo) population (n=474).
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