Performance of 18F-FDG PET/CT in the diagnosis of recurrent and metastatic endometrial cancer

Abstract

Objective To evaluate the clinical value of 18F-FDG PET/CT in the diagnosis of recurrent and metastatic endometrial cancer. Methods A total of 62 patients with endometrial cancer from October 2004 to February 2014 were retrospectively analyzed. The diagnostic efficiency of 18F-FDG PET/CT for the detection of recurrent and metastatic endometrial cancer was evaluated based on the results of pathological biopsy or clinical follow-up. Results There were 28 endometrial cancer cases with recurrence and metastasis, 9 cases with a second primary cancer and without recurrence and metastasis of endometrial carcinoma. PET/CT imaging had false positive findings in 3 cases, false negative findings in 2 cases. The overall sensitivity, specificity and accuracy of PET/CT for detection of recurrence and metastatic endometrial carcinoma were 93.3%(28/30), 90.6%(29/32), 91.9%(57/62), respectively. The sensitivity and specificity of PET/CT for the diagnosis of vaginal stump recurrence, lymph node metastasis and distant metastasis were 9/10 and 98.1%(51/52), 95.7%(22/23) and 92.3%(36/39), 15/18 and 95.5%(42/44), respectively. Conclusion 18F-FDG PET/CT is a useful diagnostic tool for the detection of recurrent and metastatic endometrial cancer and a second primary cancer. Key words: Endometrial neoplasms; Tomography, emission-computed; Tomography, X-ray computed; Deoxyglucose