Performance evaluation of multifocal electroretinography for monocular and binocular stimulation in anisochromoartiphakia

Abstract

To evaluate the difference and nature of changes in the amplitude (P1) and latency (P1, L1) parameters of mfERG in monocular (MS) and binocular stimulation (BS) in individuals with anisochromoartiphakia. The study included 24 patients aged 76.3±7.9 years with anisochromoartiphakia [one eye - IOL with yellow spectrum SN60AT (yIOL); the other is a transparent IOL - Rayacryl (trIOL)] comprising the main group, and 16 patients without artiphakia aged 51.6±4.6 years in the control group [one eye with the addition of a yellow light filter (YF) ZHS1 - a spectral analog of SN60AT, the other - without YF]. Recording of mfERG was done with MS and BS. Parameters under evaluation were DP1 (nV/deg2), amplitude P1 (mV) and latency LP1, LN1 (ms) in rings R1-R5. In general, when switching from one ring to another under both types of stimulation and spectral correction, all indicators decrease. DP1 and P1 in MS and BS in the control group (49.2±17.7 and 53.6±17.5 nV/deg2) compared to the main group were higher (42.9±15.0 and 47.7±17.3 nV/deg2), LP1 and LN1 were shorter (41.2±5.0 and 44.8±4.3 ms in the control group, 44.0±4.1 and 50.7±21.1 ms in the main group). There was a significant difference between DP1R3 and DP1R4 in the control group (p≤0.003-0.050). In the control group without YF, P1R2 under MS was statistically significantly higher than under BS (p≤0.028). LP1 of R1, R3, R5 in the intergroup comparison was statistically significantly shorter in the control group without YF and MS (p≤0.033) and with YF in R1-R3, R5 (p≤0.003-0.023). LP1R2, LP1R4 were statistically significantly higher with trIOL in the main group under MS (p≤0.015; 0.047) and with yIOL in LP1R1, LP1R4, and LR5 (p≤0.053). The intergroup comparison showed that in the main group with yIOL, LP1R5 was statistically significantly lower under MS than BS (p≤0.032). When comparing LN1 between the groups, the statistically significant difference under MS without YF was observed in R5 (p≤0.002), while the difference under BS was insignificant. For YF, the increase in LN1 was statistically significant for MS in R2 and R3 (p≤0.010; 0.037) and for BS - in R1, R2 and R4 (p≤0.037; 0.003; 0.020). The intergroup comparison revealed that in the control group without YF, LN1R2 was statistically significantly lower under MS than BS (p≤0.028), and in the main group with trIOL, LN1R3 under MS was statistically significantly lower than under BS (p≤0.041). In anisochromoartiphakia, spectral differences in the optical environment of the eye lead to changes in the parameters of mfERG in the form of a decrease in DP1 and elongation of LP1 and LN1 in comparison with healthy eye and non-spectral intraocular correction. MS or BS in mfERG does not have a significant impact on the character and value of these parameters. The use of a single-stage binocular recording of mfERG reduces the duration of the study, which is especially important when examining elderly patients.