Abstract
The Ciba.Corning ACS: 180™ is a benchtop random-access Immunoassay analyser, operating with a time-to-first result of 15 minutes and a throughput of 180 tests/hour. The system can accommodate both competitive and sandwich-format chemiluminescence assays, using paramagnetic particles as solid phase and acridinium ester as label. Up to thirteen assays can reside on-board at one time from a total menu of twenty-five assays, including thyroid, anaemia, fertility, cancer, cardiac analysis and therapeutic drug monitoring applications. User interaction is limited to loading primary tubes or sample cups onto a carousel, loading on-board supplies, entering patient information, and designating which tests will be run on each sample. An automated process track is used to move disposable test cuvettes through preheating, sample addition, reagent addition, incubation, separation and measurement steps. Robotic sample and reagent probes perform all fluid transfer actions; dispense precision of both is 1% over their delivery volume ranges (10 to 200-μL and 50-500μL respectively). Magnetic separation yields a recovery variation of less than 1% at a concentration level of 200 μg/500μL, and less than 3% of 20μg/500μL Following separation and washing of the particles, reagents are added to initiate the chemiluminescence reaction. The lumlnometer accumulates this signal over 5 seconds, with a precision of 2% at 350,000 photon counts. Data reduction is accomplished through either spline or four/five parameter logistic curve-fitting methods and is pre-programmed for each assay. Data demonstrating the performance of the ACS:180™ will be shown.
Published Version
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