Performance assessment of pocket tunnel FET and accumulation mode FET for detection of streptavidin protein

Abstract

In this paper, Dielectrically Modulated (DM) pocket Tunnel Field Effect Transistor (TFET) and Accumulation Mode Field Effect Transistor (AMFET) biosensors are examined for the Sensitivity estimation of different thicknesses of biotarget (Streptavidin)/bioreceptor (Biotin)/silica binding protein (SBP or APTES) biomolecules with a fully filled and partially filled cavity. The sensitivity parameter is based on realistic process detection and is calculated as the ratio of biotarget to bioreceptor drain current for neutral and charged biomolecules. The effect on the sensitivity for a filled cavity is observed for: a) varying the thickness of streptavidin and Biotin for fixed SBP (APTES) thickness, b) varying the thickness of streptavidin and APTES for fixed biotin thickness, for both Pocket TFET and AMFET. The maximum sensitivity is observed in 4 nm thick streptavidin for the front gate voltage V fg: −3.8 V and V fg: −1.6 V for pocket TFET and AMFET, respectively.