Abstract
Perforating collagenosis is an uncommon distinct dermatosis characterized by transepidermal elimination of altered collagen through the epidermis. It was first described by Mehergan et al in 1967 and till date etiology of this disease is unknown. Herein, we describe a case of acquired perforating collagenosis in a 16 year old male who presented with multiple discrete pruritic and hyperkeratotic umblicated lesions on trunk, upper and lower extrmities and scalp for more than three years. Skin biopsy revealed a typical hyperkeratotic papule with a central plug, surrounding epidermal hyperplasia, inflammatory cells and vertically oriented fibers of collagen. On Masson's trichrome staining, perforating bundles of collagen were seen extending to the surface. A diagnosis of perforating collagenosis was made. The patient during follow up subsequently developed solitary nodule over the anterior chest wall which on histopathological examination revealed well circumscribed spindle shaped neoplasm in the dermis. These cells exibited wavy nuclei in a collagenous stroma along with proliferation of Schwann cells and fibroblasts. In view of these findings, the diagnosis was modified to reactive perforating collagenosis with cutaneous neurofibroma.
Published Version
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