Abstract
The influence of incorporation of the dopants with proton-acceptor properties into perfluorosulfonic acid cation exchange membranes (MF-4SC and Nafion), and their treatment conditions on the characteristics of Donnan potential (DP)-sensors (analytical signal is the Donnan potential) in the aqueous solutions containing asparaginate and potassium ions in a wide pH range was investigated. A silica, surface modified by 3-aminopropyl and 3-(2-imidazolin-1-yl)-propyl groups, was used as the dopant. The membranes were subjected to mechanical deformation and thermal treatment at various relative humidities. The relationship between water uptake and diffusion permeability of membranes subjected to modification and treatment and the cross sensitivity of DP-sensors based on them to counter and co-ions was studied. The multisensory systems for the simultaneous determination of asparaginate and potassium ions in a concentration range from 1.0 × 10−4 to 1.0 × 10−2 M and pH range from 4 to 8 were developed. An array of cross-sensitive DP-sensors based on MF-4SC membranes containing 3 wt.% SiO2 modified by 10 mol.% 3-aminopropyl and 3-(2-imidazolin-1-yl)-propyl was used for the potassium asparaginate hemihydrate and magnesium asparaginate pentahydrate determination in Panangin® (with an error of 2 and 4%, respectively).
Highlights
Asparaginates of alkali, alkaline earth, and some transition metals are active substances of antiarrhythmic pharmaceuticals
Sensors based on graphite electrodes modified by a molecularly imprinted polymer film with titanium dioxide nanoparticles and multiwall carbon nanotubes (MWCNTs) [1] or by gold nanoparticles and MWCNTs [2] were developed for determination of D- and L-aspartic acid in the model solutions, blood serum, cerebrospinal fluid, and pharmaceuticals using differential pulse inversion voltammetry
The aim of this work was the development of a multisensory system with Donnan potential (DP)-sensors based on perfluorosulfonic acid cation exchange membranes (MF-4SC and Nafion) modified by silica with nitrogen-containing groups, as well as the investigation of thermal treatment at the various relative humidities and mechanical deformation influence on the simultaneous determination of asparaginate and potassium ions in the aqueous solutions and pharmaceuticals
Summary
Asparaginates of alkali, alkaline earth, and some transition metals are active substances of antiarrhythmic pharmaceuticals. Voltammetric sensors are used for determination of asparaginate ions in pharmaceutical and physiological environments most often [1,2,3]. Sensors based on graphite electrodes modified by a molecularly imprinted polymer film with titanium dioxide nanoparticles and multiwall carbon nanotubes (MWCNTs) [1] or by gold nanoparticles and MWCNTs [2] were developed for determination of D- and L-aspartic acid in the model solutions, blood serum, cerebrospinal fluid, and pharmaceuticals using differential pulse inversion voltammetry. Membranes 2019, 9, 142 by copper micro- and nanoparticles were proposed for the investigation of electrocatalytic oxidation and for the determination of amino acids, in particular, aspartic acid, in the model solutions [3]. An amperometric biosensor based on platinum electrode with an enzyme membrane immobilized on its surface was designed for determination of L-aspartic acid in the model solutions [4]
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