Perfluorodecalin Emulsion Tested for Biocompatibility in Macrophages by Means of a Magnetometric Method

Abstract

The effect of a stable perfluorodecalin (FDC) emulsion, based on addition of 0.2-0.5% (W/V) of perfluoroperhydrophenanthrene and 4% egg yolk lecithin was tested for its influence on Kupffer cells in vivo by means of a magnetometric procedure in rats. It was also compared with the effect of a perfluoro-chemical emulsion (PFC) of the first generation (FluosolR-DA, FDA). While doses of 0.1 g/kg body weight of both PFCs caused a small increase of activity in these cells (as measured by an increase in a ratio factor r after magnetization), doses of 1 g/kg b.wt. led to a significant retardation of intracellular movements after FDC and FDA for two and four days, respectively. A dose of 3 g/kg b.wt. of FDC effected a significant depression for 8 days, whereas after the same dose of Fluosol-DA the intracellular motility remained depressed for as long as 32 days.