Abstract
Liquid-assisted ventilation LAV with PFC has been shown to be beneficial in treating a variety of respiratory diseases in animals and humans. While PFC evaporation from the lungs is in part dependent on ventilation strategy and positioning, guidelines for initial and replacement dosing are unclear. We hypothesized that PFC evaporative loss (EL)profile over time is dependent upon initial dosing. To test this hypothesis, PFC(perflubron:LiquiVent) was instilled endotracheally over 3-5 minutes using three initial volumes (GR I=2ml/kg, GR II=6 ml/kg, GR III =17ml/kg) while repositioning to optimize distribution. Juvenile rabbits (wt =2.2±.7 kg; n=11) were ventilated using a constant position & ventilator strategy: frequency =30br/min, tidal volume= 10.7±.13 ml/kg, Vm=325±4.2 ml/min/kg. A previously described thermal detector device measured PFC content in expired gas and was used to calculate EL profile[loss rate C'PFC (ml/kg/hr) and residual PFC in the lung RPFC (% initial dose)] up to 4 hrs after initial dosing. Data expressed as (Mean±SE). There was a significant dose, time, and dose-time interaction such that EL profile was dependent on initial PFC volume and time after fill (p<0.05). The total perflubron loss over 4 hrs was 0.96ml/kg(GR I); 3.1ml/kg(GR II); 4.6ml/kg(GR III). The R PFC after 4 hrs was 52±2.6%(GR I), 45±6.7%(GR II); 74±2.4%(GR III). We conclude that EL profile is dependent upon initial PFC dose and time after dosing. Thus, in addition to ventilation strategy and positioning, EL profile should be considered in order to optimize replacement dosing. Table
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.