Abstract
Stimuli-responsive microcarriers have received considerable attention in a variety of fields, including disease diagnosis, drug delivery, sensing and imaging. Here, we report the generation of multiple-responsive perfluorocarbon-loaded magnetic hydrogel microcapsules (PMHMs) with uniform size for magnetic controlled ultrasound (US) and laser activation. The PMHMs are fabricated by a novel coaxial interface shearing (CIS) method based on the mechanism of liquid bridge formation and fracture. Perfluorocarbon and iron oxide magnetic nanoparticles (MNPs) are used as US-responsive and photothermal absorption medium respectively, and MNPs are also used for magnetic-controlled targeting. Moreover, the size, structure, and function of the prepared biocompatible PMHMs can be precisely controlled by adjusting the process parameters of CIS. It is indicated that the PMHMs have different US- and light-responsive characteristics, mainly because of the difference of their activation mechanisms. It is demonstrated that laser has better activation resolution and can achieve site-specific activation and drug release of PMHMs. The multiple-responsive features imply that the PMHMs fabricated by CIS may provide an effective drug release platform for biomedical and pharmaceutical applications.
Highlights
The advanced drug delivery system (DDS) can deliver drugs to the target organ, and effectively adjust the physicochemical properties of the drug, to improve treatment effect, reduce toxic and side effects, and save treatment cost [1,2,3,4,5]
The outer shell of perfluorocarbon-loaded magnetic hydrogel microcapsules (PMHMs) is PNIPAM combined with magnetic nanoparticles (MNPs) and the inner core is USresponsive PFC liquid which makes the PMHMs have magnetic, US, and photothermal-responsive characteristics
The size, structure of the PMHM can be precisely adjusted in a wide range by controlling the experimental parameters
Summary
The advanced drug delivery system (DDS) can deliver drugs to the target organ, and effectively adjust the physicochemical properties of the drug, to improve treatment effect, reduce toxic and side effects, and save treatment cost [1,2,3,4,5]. As a novel DDS, stimuli-responsive microcarriers (SRMs) can release drugs on demand under stimuli, which can further manipulate drug release behaviors and improve therapeutic effect [4, 5]. The physicochemical properties of SRMs, such as size, structure, shape, and composition are vital for drug release process under stimuli. Used stimuli methods include physical- (such as light, heat, electric field, and ultrasound) and chemical-based stimuli methods (such as enzymes, pH, and glucose). The emerging physical-based stimuli methods such as ultrasound (US) and laser offer a convenient and robust controlled drug release platform and have attracted extensive interest [6,7,8,9,10,11,12,13]
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
