Abstract
The three-component Mannich-type reactions of different ketones with various aromatic aldehydes and aromatic amines proceeds efficiently in the presence of catalytic amount of perfluoroalkylated-pyridine in a fluorous biphasic system without fluorous solvent, which has prompted various concerns involving cost, solvent leaching, and environmental persistence. The reactions give various β-arylamino ketones in good to excellent yield. The catalyst can be recovered by simple cooling and precipitation and used again.
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