Abstract
Introduction: Prenatal exposure to perfluoroalkyl substances (PFAS) may affect child growth; thus estimating PFAS fetal body burden is relevant. PFAS fetal burden is considered best estimated in cord samples; however previous cohort studies have used either maternal plasma or serum indistinctively during pregnancy as proxy. We evaluated the correlations and the transfer ratio between PFAS concentration in maternal plasma and serum in pregnancy, and cord serum at birth in a Spanish birth cohort. Methods: We measured perfluorobutanesulfonic acid (PFBS), perfluorohexanesulfonic acid (PFHxS), perfluorooctanesulfonic acid (PFOS), perfluorooctanoic acid (PFOA), and perfluorononanoic acid (PFNA) in 67 mother-child pairs. We assessed the correlations between PFAS concentrations in first trimester maternal plasma and serum, with cord serum samples using the Spearman's rank coefficients. We evaluated PFAS transfer from mother to fetus using maternal to cord ratios. Results: Median concentrations (ng/mL) of PFHxS, PFOS, PFOA, and PFNA in maternal plasma (0.76, 6.14, 2.82 and 0.84, respectively) and serum (0.84, 6.73, 3.14 and 0.86) were higher than in cord serum (0.40, 1.87, 1.90 and 0.33). PFBS was not detected. Strong positive correlations (p-values
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