Abstract
Multi component condensation of an aryl aldehyde, acetyl chloride, acetonitrile and enolisable ketone in presence of Nafion-H, as an efficient, environment friendly heterogenous and recyclable catalyst for the one-pot synthesis of β-acetamido ketones in high yields is described.
Highlights
Introduction β-Acetamido ketones are considered as versatile intermediates as their basic skeleton exist in a number of biologically or pharmacologically important compounds.[1,2]. These compounds are useful in the synthesis of other important organic molecules like 1,3-amino alcohols 3, 4 units common in natural nucleoside peptide antibiotics, e.g., nikkomycines or neopolyoxins.[5,6]
Synthetic strategies based on one-pot multicomponent reactions overriding the conventional linear type synthesis and considered as powerful tools in the modern drug discovery process.[7]
The Nafion-H catalyst, an insoluble resin is inert to corrosive environments, stable up to 201 0C, easy to recover and to reuse
Summary
Perfluorinated resin-sulfonic acid (Nafion-H): an efficient, environment friendly and recyclable heterogeneous catalyst for the one-pot multicomponent synthesis of β-acetamido ketones.
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