Perfil hormonal preoperatorio en pacientes sometidos a prostatectomía radical por cáncer de próstata

Abstract

ObjectiveThere is controversial evidence regarding preoperative testosterone (T) levels related to poor prognosis factors after radical prostatectomy (RP). The aim of this manuscript is to determine the relationship between preoperative T levels and final pathologic report together to biochemical recurrence after RP. Materials and methodsWe prospectively analysed 143 patients submitted to RP from February 2008 to June 2010 in our centre. Pretreatment T and sex hormone-binding globulin levels were determined as part of our clinical protocol. Free calculated (fT) and bioavailable (bioT) T were calculated using Vermeulen's formula. Low T levels were defined as 346ng/dL or less. A comparative analysis with variables pTNM, positive margins, tumour burden, Gleason score, multifocality and biochemical recurrence (using both PSA>0.4ng/dL and PSA>0.2ng/dL as cut-off values) was performed, according to preoperative levels of T. ResultsVariables Gleason score, rate and number of positive margins, tumour burden, tumour multifocality, time to biochemical recurrence and pathological stage were not related to preoperative hormonal levels. Preoperative T<346ng/dL was not found to be related to PSA recurrence (PSA>0,4ng/dL log-rank, P=.512), although a trend was observed when PSA>0,2ng/dL (log-rank, P=.097). ConclusionPreoperative T levels were not related to final pathological report or to biochemical recurrence.