Peretinoin protects against IL-1β induced inflammation and matrix degradation in primary human chondrocytes by inhibiting P-38 MAPK signaling

Abstract

Purpose: Peretinoin (PRT) is a synthetic acyclic retinoid and has potential chemo-preventive activity. Osteoarthritis (OA) is characterized by (a) increased local inflammation, (b) increase in the cartilage matrix catabolic factors, and (c) decrease in the expression of anabolic factors. In this study, we evaluated the effects of PRT on the (a) expression of inflammatory mediators, (b) matrix-degrading proteases and (c) anabolic factors in primary human OA chondrocytes and investigated the associated signaling pathways affected by PRT treatment under pathological condition (stimulation with IL-1β).