Peretinoin, an Acyclic Retinoid, for the Secondary Prevention of Hepatocellular Carcinoma.

Hyun Young Woo,So Young Yoo,Jeong Heo

doi:10.3390/molecules26020295

Abstract

The high rates of hepatocellular carcinoma (HCC) recurrence after initially successful curative therapy emphasize ongoing unmet needs to prevent or reduce HCC recurrence. Retinoid acid (RA), a metabolite of vitamin A and its related analogues (termed retinoids) has been suggested as a promising chemotherapeutic agent in cancer treatment. The synthetic oral retinoid peretinoin is the only agent for the secondary chemoprevention of HCC after curative therapy that is currently well applied into clinical development. Here we present an updated summary of the molecular pathogenesis of HCC and of preclinical and clinical findings with peretinoin, including its clinical characteristics, safety and tolerability profile and future perspectives for clinical use.

Highlights

This review investigated the current status and prospects of peretinoin, an acyclic retinoid (ACR) compound developed for secondary prevention of hepatocellular carcinoma (HCC)
The results showed that, in the non-recurrence group, differentiation of hepatocytes and expression of the genes involved in tumor suppression were accelerated, while expression of the genes involved in promotion of liver fibrosis and lipidation, as well as the genes which can become markers for the stem cells of hepatic cancer was reduced
The overall hazard ratio (HR) for risk of HCC recurrence/death in the 600 mg/day group was not significant, the HR during the second year of treatment was significant (HR 0.267, 95% confidence interval [CI] 0.074–0.961). These results suggested that twice daily administration of 600 mg/day peretinoin was clinically effective in preventing the recurrence of HCC [42]

Summary

Introduction

Peretinoin, An Acyclic Retinoid, for the Secondary Prevention of Hepatocellular Carcinoma. Publisher’s Note: MDPI stays neutral with regard to jurisdictional claims in published maps and institutional affiliations.

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Discussion

Conclusion