Abstract
• Three new cytochalasins were isolated from the fungus Perenniporia subacida • The structures were established by means of spectroscopic data. • Cytochalasans are found from this fungus for the first time. • Two new compounds showed cytotoxicity to human cancer cell lines and one inhibited NO production. Fungi are important resources for the discovery of bioactive natural products or leading compounds. In our continuous searching for bioactive metabolites from fungi, three previously undescribed cytochalasans, perennisubacins A–C ( 1 ‒ 3 ), together with three known analogues 4 ‒ 6 , were isolated from the fungus Perenniporia subacida . Their structures were established by means of spectroscopic methods. Compound 1 showed cytotoxicity against SMMC-7721 with an IC 50 value of 23.3 μ M, while compound 3 showed cytotoxicity against A-549 with an IC 50 value of 37.6 μ M. In addition, compound 3 inhibited nitric oxide (NO) production with an IC 50 value of 18.4 μ M. This is the first report of cytochalasins from the fungus P. subacida and their bioactivities.
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