Abstract
The percentage penetration of N,N-diethyl- m-toluamide ( m-deet) and 2-ethyl-1,3-hexanediol (ethylhexanediol) was determined on hairless dogs at a dose of 4 μg/cm 2, and these results were compared with corresponding data at 320 μg/cm 2. In addition, the percentage percutaneous penetration for n-butanesulphonamide cyclohexamethylene (sulphonamide), an experimental mosquito repellent, was determined at doses of 100, 320 and 1000 μg/cm 2 in the hairless dog. The mean percentage penetration was found to decrease with increasing chemical dose for sulphonamide and m-deet, and to increase slightly with ethylhexanediol, but none of these changes differed significantly at the 95% confidence level.
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