Abstract
Nephrolithiasis accelerates the renal failure in the patients with ADPKD. In order to evaluate the role of percutaneous nephrolithotomy in management of calculus in these patients, 11 patients with autosomal dominant polycystic kidney disease and renal stones were included in the study. Two patients had bilateral renal stones. All patients were treated by percutaneous nephrolithotomy under ultrasound guidance. 13 percutaneous nephrolithotomy procedures were performed in 1 stage by the urology team under ultrasound guidance. 5 people received second operation with flexible nephroscopy in lateral position. The success rate and morbidity and mortality of the technique and hospital stay were recorded. Results. The puncture procedure was fully successful in all cases. The renal function improved in these patients. 5 patients had moderate fever after the surgery. 5 patients received flexible nephroscopy to take out the residual calculi. 2 persons had ESWL therapy after the surgery. Conclusion. PCNL is an ideal, safe, and effective method to remove the stones from those patients with no definite increase in the risk of complication. The outcome and stone-free rate are satisfactory comparable to the PCNL in the patients without ADPKD.
Highlights
Autosomal dominant polycystic kidney disease (ADPKD) is characterized by the progressive development of multiple renal cysts that destroy the renal parenchyma
70% of patients with ADPKD will progress to renal failure at a median age of 56 [1]
Percutaneous nephrolithotomy is considered as the most effective treatment for the patients with larger upper urinary calculi in these days, there are still many people doubts about the safety and efficacy for this technique in the patients with ADPKD and nephrolithiasis
Summary
Autosomal dominant polycystic kidney disease (ADPKD) is characterized by the progressive development of multiple renal cysts that destroy the renal parenchyma. It is the most common genetic disorder leading to end stage renal disease. In the early stages of ADPKD, most of the patients show a stable period of mild to moderate renal failure, which later on hastened by urinary infection and nephrolithiasis [2]. Percutaneous nephrolithotomy is considered as the most effective treatment for the patients with larger upper urinary calculi in these days, there are still many people doubts about the safety and efficacy for this technique in the patients with ADPKD and nephrolithiasis. We evaluated the safety and efficacy of this procedure
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