Abstract
Objectives: To evaluate the efficacy and safety of RIRS and PCNL in treatment of renal stone size between 1-2.5cm.
 Methods: This comparative prospective study was conducted in the Department of Urology of a tertiary care teaching hospital of Rajasthan from January 2019 to June 2020. Patients were fully informed about the study protocol and a written informed consent has obtained from patients with renal stone disease without any co-morbid conditions, posted for RIRS and PCNL. Stone free rate, post operative complications, hospital stay, operation time and cost between RIRS and PCNL for treatment of renal stone size between 1-2.5cm were compared.
 Results: Out of total 313 patients, 212 patients underwent PCNL and 101 patients RIRS. The stone clearance rate was significantly better in PCNL (92.45%) than RIRS (85.15%). The hospital stay was significantly less in RIRS (2.02±1.36 days) when compared to PCNL (3.89±2.18 days). Mean operative time for PCNL was significantly less i.e. 71.81±12.89 minutes as compared to 85.79±13.94 minutes in RIRS. Post-operative complications were more in PCNL group than RIRS.
 Conclusions: This study concluded that PCNL when compared to RIRS both have advantages and disadvantages according to size and location of stone, post-operative complications, stone free rate and operation cost. Judicious use of PCNL and RIRS should be done according to above mentioned parameters.
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