Abstract
We investigated in vitro the percutaneous absorption of tritiated digoxin in normal saline using Franz-type diffusion cells. Across mouse skin, the diffusion rate ( J) and permeability coefficient ( K p) were respectively equal to 55.4 ± 19 pg/cm 2 per h and 0.14 ± 0.04 × 10 −3 cm/h. When PEG 400 and ethanol were added to the receptor compartment, the flux increased to 233.4 ± 109.5 pg/cm 2 per h and K p rose to 0.60 ± 0.28 × 10 −3 cm/h. Under the same conditions, percutaneous absorption across human skin was dramatically lower ( J = 6.0 ± 1.5 pg/cm 2 per h, K p = 0.016 ± 0.008 × 10 −3 cm/h). This is explained by the dermal retention of this lipophilic molecule.
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