Abstract
AbstractThe percutaneous absorption of lidocaine hydrochloride was investigated in vivo using the hairless (hr-1/hr-1) mouse as an experimental model. Following topical application of 2 mg lidocaine hydrochloride in concentrated aqueous solution, concentrations of the drug were measured in plasma obtained at 1, 2, 4, and 6 hr. The mean plasma concentrations ranged from 0.2 to 0.3 mg/1 over the 6 hr study period while individual concentrations were as high as 2.4 mg/1. With each successive hour, peak plasma concentrations increased. This study suggests that percutaneous absorption could be a convenient route for prolonged administration of lidocaine hydrochloride and could conceivably yield plasma concentrations approaching the therapeutic range for antiarrhythmic control in humans. This information may also be important for persons using the drug as a topical anesthetic.
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