Abstract
BackgroundOsteoporosis (OP) is a systemic metabolic bone disorder identified as an essential health issue worldwide. Orthopedic imaging approaches were commonly used with some limitations. Thus, our study aimed to investigate the diagnostic value of magnetic resonance spectroscopy (1-H MRS) and m-Dixon-Quant in OP.MethodsA total of 76 subjects were enrolled in the study and bone mineral density (BMD) was measured using quantitative computed tomography (QCT). Then, the subjects were divided into three groups according to BMD: normal control group, osteopenia group and OP group. The following parameters were recorded for each patient: gender, age, height, body weight, waist circumference, and hip circumference. Further, the fat fraction percentage (FF%) values were determined by 1-H MRS and m-Dixon-Quant methods.ResultsIn both 1-H MRS and magnetic resonance Imaging (MRI) m-Dixon-Quant, the FF% exhibited a negative correlation with BMD (P < 0.05). The FF% value of the OP group was significantly higher than that of the control group (P < 0.05). In addition, the FF% value in the m-Dixon scans was positively related to age, while BMD showed a negative linear relationship with age (P < 0.0001). Further, females had a significantly higher FF% value compared to males (P < 0.01), and height was correlated with BMD (P < 0.05) but not with FF% (P > 0.05).ConclusionsMRI investigations especially FF% value in the m-Dixon-Quant imaging system is correlated with OP. Its diagnostic value remains to be demonstrated on a large prospective cohort of patients. Besides, parameters such as age, gender, and height are important factors for predicting and diagnosing OP.
Highlights
Osteoporosis (OP) is a systemic metabolic bone disorder identified as an essential health issue worldwide
fat fraction (FF) is negatively correlated with bone density First, the parameter FF% was used in both 1H MR spectroscopy (MRS) and m-Dixon-Quant methods, and the results showed that the average bone mineral density (BMD) had a negative relationship with FF% value
We proposed that FF% played a crucial role in magnetic resonance Imaging (MRI)-based OP assessments and our results provided a potentially novel strategy for preventing and treating OP that extends beyond BMD observation
Summary
Osteoporosis (OP) is a systemic metabolic bone disorder identified as an essential health issue worldwide. Osteoporosis (OP) is a systemic metabolic bone disorder that affects more than 200 million people especially the elderly worldwide [1]. It is characterized by reduced bone density, leading to an increase in bone fragility and susceptibility to fractures, most commonly vertebral compression fracture (VCF) [2, 3]. The formation of bone, Since the 1990s, the World Health Organization (WHO) has defined OP based on the BMD determined by dual-energy X-ray absorptiometry (DXA), which has been used worldwide [6]. BMD evaluation by DXA has several known limitations since patients were commonly misclassified as having false-
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