Abstract
Typhoid disease is an acute systemic disease affecting the small intestine caused by Salmonella typhi. Treatment of tifodic fever can be done by medical or traditional means. One way of medical weighting is with antibiotic therapy. However, this time encouraged the existence of traditional medicine using earthworm Lumbricus rubellus. This study aims to determine the difference in sensitivity between antibiotic therapy with earthworm extract of Lumbricus rubellus in inhibiting Salmonella typhi growth in vitro. This research was experimental with bacterium isolate Salmonella typhi 0.5 Mc. Farland with Lumbricus rubellus earthworm extract in the form of infusa 15%, 30%, 45%, 60%, 75%, and 90% and various antibiotics that is Ampsisilin, Amoxicilin- Clavulanic acid, Cefuroxime, Chloramphenicol, Trimetophim, Sulfamethoxazole, Ceftriaxone, Meropenem, Cefotaxim, Levoflaxacin, Ceftazidim, and Cefepime were tested using the diffusion method. Observations were made by calculating the drag zone diameter in Mueller Hinton media. The results showed that there were significant differences between Lumbricus rubellus earthworm extract and antibiotic therapy, whereas in all concentrations of Lumbricus rubellus earthworm extract were resistant, whereas in all antibiotics were sensitive to Levoflaxacin type which had a large inhibitory diameter of 34 mm.
 
 Keywords: Typhoid Fever, Salmonella typhi, Lumbricus rubellus Earthworm Extract, Antibiotic Therapy.
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