Per oral endoscopic myotomy vs. laparoscopic Heller myotomy, does gastric extension length matter?

Abstract

To report our experience in POEM vs. LHM, with particular focus on myotomy extension. POEM has been adopted worldwide as a treatment for achalasia. While resolution of dysphagia is above 90%, postoperative reflux ranges from 10 to 57%. Myotomy length has been a controversial topic. Thirty-five cases of POEM were prospectively analyzed and compared retrospectively to the last 35 patients that underwent LHM, from December 2010 to August 2016. Mean follow-up was 10months (6/32) for POEM and 20months (6/68) for LHM. All patients with LHM had a myotomy extension ≥3cm on the gastric side. In POEM cases, extension was defined by direct vision (Hill type II) and never exceeded 2cm. Follow-up was completed in 100% of patients. Efficacy (ES≤3) was 33/35 (94.2%) for POEM and 32/35 (91.4%) for LHM in a short-term follow-up (p=1.000) and 31/35 (88.6%) and 27/35 (77.1%), respectively, in a long-term follow-up (p=1.000), with average ES drop from 9 to 1.2 (p=0.0001) in POEM vs. 9.2 to 1.3 (p=0.0001) in LHM. Major Postoperative complications occurred in 1 patient (leak) for LHM and 1 patient (massive capnothorax) in POEM. Hospital stay was shorter for POEM than for LHM (1.3 vs. 2.1, respectively) (p=0.0001). Symptomatic reflux cases included 7/35 POEM (20%) vs. 6/35 LHM (17.1%) (p=0.4620). Esophagitis signs in endoscopy appeared in 1/21 POEM (4.7%) vs. 1/22 LHM (4.5%) (p=1.000). Patients requiring PPI included 8/35 POEM (22.8%) vs. 7/35 LHM (20%) (p=0.6642). Further treatment (endoscopic dilation) was performed in 10/35 POEM (28.5%) vs. 8/35 LHM (22.8%). A shorter myotomy on the gastric side in POEM may contribute to an acceptable reflux rate with comparable relief of dysphagia. Although our follow-up for POEM is shorter than for LHM, the trends are promising and warrant future prospective studies to address this topic.