Per- and Polyfluorinated Substances (PFAS); a Literature Review

Abstract

This literature review aims to assess contemporary research on human exposure to Per- and Polyfluorinated Substances (PFAS) using the PubMed database. A series of research papers were acquired and examined, revealing novel exposure routes (firefighting, blood transfusions), associations with renal cell carcinoma, impact on DNA methylation, and links to pregnancy and early infant health. PFAS is also associated with adiposity, heart disease, and impaired immune response post-vaccination. The literature suggests potential interventions through blood and plasma donations. Limitations in the scope and scale of research, along with gaps in the understanding of the carcinogenic potential of PFAS and the efficacy of interventions in reducing PFAS exposure, were identified. Further public health research should address these gaps and limitations to enhance our understanding and address the negative health outcomes associated with PFAS exposure.