Peptides/Proteins Encoded by Non-coding RNA: A Novel Resource Bank for Drug Targets and Biomarkers.

Song Zhu,Jizhong Wang,Yutian He,Guang-Rong Yan,Nan Meng

doi:10.3389/fphar.2018.01295

Abstract

Non-coding RNAs (ncRNAs) are defined as RNA molecules that do not encode proteins, but recent evidence has proven that peptides/proteins encoded by ncRNAs do indeed exist and usually contain less than 100 amino acids. These peptides/proteins play an important role in regulating tumor energy metabolism, epithelial to mesenchymal transition of cancer cells, the stability of the c-Myc oncoprotein, and the ubiquitination and degradation of proliferating cell nuclear antigen (PCNA). These peptides/proteins represent promising drug targets for fighting against tumor growth or biomarkers for predicting the prognosis of cancer patients. In this review, we summarize the characteristics of peptides/proteins that have recently been identified as putative ncRNA translation products and their outlook for small molecule peptide drugs, drug targets, and biomarkers.

Highlights

Non-coding RNAs comprise a class of RNA nucleic acid molecules that are transcribed from DNA but do not encode proteins (Guttman et al, 2013)
HOXB-AS3 plays an important role in regulating tumor energy metabolism, and small regulatory peptide of amino acid response” (SPAR) interacts with the lysosomal v-ATPase to negatively regulate mTORC1 activation
We describe a bank of biologically functional peptides/proteins encoded by long non-coding RNA (lncRNA), circular RNA (circRNA), and pri-miRNA

Summary

INTRODUCTION

Non-coding RNAs (ncRNAs) comprise a class of RNA nucleic acid molecules that are transcribed from DNA but do not encode proteins (Guttman et al, 2013). The ideal drug has specificity and pharmacological activity, but can reach the target site to play a role Whether these cancer-suppressive peptides/small proteins (SPAR, HOXBAS3, FBXW7-185aa, SHPRH-146aa, miPEP-200a, and miPEP200b) encoded by ncRNAs, are secreted into human serum remains unknown. Whether they can enter tumor cells through transporters on the cell membrane and play an inhibitory role remains unknown. After the coding sequence of these peptides/small proteins is recombined with adenovirus, it could be injected into patients to treat tumors

Targeted Therapy

Biomarkers in Clinical Detection

Findings

CONCLUSION