Abstract
DNA has been used for decades as a convenient chemical for storing information, thanks to its ease of synthesis and decoding. Scientists have used DNA tags to encode information in massive chemical libraries, which has been useful in drug discovery. In these DNA-encoded libraries , or DELs, the DNA holds the directions for making the small molecule to which it is linked. Now, chemists at the Massachusetts Institute of Technology are offering another approach to storing information for small-molecule libraries: peptides. These peptide-encoded libraries (PELs) were developed by professors Stephen L. Buchwald and Bradley L. Pentelute along with postdoctoral scholars Simon L. Rössler and Nathalie M. Grob. The PELs offer increased density for information storage because they use 16 noncanonical amino acids as storage units, versus DNA’s 4 units. Because peptides also boast greater stability than DNA, they can be easier to use in certain types of chemical synthesis when
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